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These receptors can also assemble inflammasome complexes, such as NLR family pyrin domain containing 3 (NLRP3), in coordination with absent in melanoma 2 (AIM2), resulting in the release of pro-inflammatory cytokinesincluding interleukin-1 (IL-1), IL-18, and TNF-and thereby amplifying neuroinflammation (Harms et al., 2021

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Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma